Celiac Disease

        Celiac disease ( allergy to Gluten )

Coeliac disease or celiac disease is an autoimmune disorder of the small bowel that occurs in genetically-predisposed individuals. It is caused by an abnormal reaction to gliadin, a gluten protein found in wheat, barley, spelt, Kamut and rye. A small minority   of coeliac patients also react to oats. Upon exposure to gliadin, the body's immune system cross-reacts with the enzyme tissue transglutaminase, causing flattening of the villi lining the small intestine, which interferes with the absorption of nutrients. The only effective treatment is a diet, lifelong in principle, from which gluten is absent.

This condition has several other names, including: cœliac disease (with ligature), c(o)eliac sprue, non-tropical sprue, gluten enteropathy, and gluten intolerance.

                                        

Signs and symptoms

The diverse range of coeliac disease symptoms may make it difficult to diagnose. There are over two hundred symptoms that have been identified; not all people have the same symptoms; some people have no symptoms at all; and the symptoms may mimic other diseases. Comprehensive lists are available. 

Gastrointestinal or digestive problems occur in some coeliacs. It used to be thought that all coeliacs had diarrhea, weight loss, and nutritional deficiencies, but it is now known that only a small percentage have these symptoms. There is a wide range of digestive symptoms including canker sores, diarrhea, constipation, and nausea. Many of the symptoms may mimic other diseases such as irritable bowel syndrome, reflux, or even Crohn's disease and coeliac may be misdiagnosed as any of these. Other symptoms that may occur are bulky, pale, offensive-smelling stools which may float in the toilet bowl, excess flatulence, infrequent, minor rectal bleeding, or persistent pain in the abdomen.

Some symptoms appear to be caused because the villi are unable to absorb nutrients. Some examples are osteoporosis, damage to teeth enamel, anemia, fatigue, rapid or unexplained weight loss, overweight, failure to thrive or stunted growth in children, etc. Yet other symptoms appear to be emotional, such as depression and irritability. Dermatitis herpetiformis is an itchy blistering skin disease that occurs in some coeliacs and is considered to be an external manifestation of coeliac disease.

While some untreated coeliacs may be symptom-free, they are still doing damage to their small intestines. Regardless of the presence or absence of symptoms, the disorder is associated with an increased risk of osteoporosis, miscarriage (but not infertility), certain types of chronic renal disease, certain types of intestinal cancers, and other auto-immune disorders.

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Diagnosis

The condition is frequently misdiagnosed or overlooked as it can exhibit multiple symptoms and often the patient or medical staff may not link seemingly unconnected conditions. It is most frequently misdiagnosed when the sufferer complains of diarrhea, persistent indigestion, a rash or irritable bowel syndrome.

There are several tests that can be used to assist in diagnosis. The level of symptoms may determine the order of the tests, but all tests must be done while the person is on a gluten containing diet. Antibodies are reduced and intestinal damage begins to heal immediately upon removing all gluten from the diet, so the risk of misdiagnosis is increased if the person is not eating gluten.

The first tests to be run are usually blood tests. These are discussed in detail below. It is possible for a person to have negative results, however, and still have coeliac disease. If indicated, either because of positive blood tests, or because test results were not consistent by family history or symptoms are, the next step in diagnosis is through a biopsy. This is considered the "gold standard" test that definitively determines if a person has coeliac disease.

An upper endoscopy with biopsy of the distal duodenum or jejunum is performed. It is important for the physician to obtain multiple samples from various places throughout the intestine. However, upper endoscopy carries a risk of false negative results. This is because coeliac disease may or may not damage villi throughout the entire small intestine, and upper endoscopy only examines the upper part of the intestine. In a patient whose intestinal damage is located further down, the biopsy may come   back negative.
If the endoscopy is positive, then the diagnosis is confirmed. If the endoscopy is negative, the diagnosis is not necessarily excluded.

For people with Dermatitis Herpetiformis (DH) different tests are used, as not all of them will also have damaged villi, though up to 85% do according to the Celiac Disease Foundation. A biopsy of a skin lesion and staining for IgA in the tissues is  completed.

Tests

Serology has been proposed as a screening measure, because the presence in the blood of IgA antibodies reactive against  gliadin and tissue transglutaminase is indicative of coeliac disease. To show antibodies, the person must be consuming gluten. These tests can be used both to identify coeliac disease and as an annual test to ensure that the coeliac is not ingesting gluten.

A thorough workup includes four tests:

1- Anti-tissue transglutaminase Antibody (tTG), IgA. This test is sometimes used alone. If this test is positive it is highly likely  that the patient has coeliac disease. tTG test is not reliable in children before the age of 2.

2- Anti-gliadin antibodies (AGA), IgG and IgA. These tests are often useful when testing young symptomatic children, but they are found in fewer coeliacs than Anti-tTG, and their presence does not automatically indicate coeliac disease because they are found in some other disorders. Some people have an IgA deficiency. They are unable to mount an IgA response to any antigen and will have false negative tests for the IgA type coeliac tests. Yet IgA deficiency is associated with coeliac disease and a tenfold risk of coeliac disease has been documented in selective IgA deficiency.

3- Anti-endomysial antibodies (EMA), IgA. This test is being replaced by the anti-tTG test because both tests measure the autoantibodies that cause the tissue damage associated with coeliac disease. Many physicians still order this test. This test as  tTG test is also not reliable in children before the age of 2. 
An older test, the anti-reticulin antibodies (ARA), IgA. IgA Anti-ARA is not ordered as frequently as it once was, because it is less sensitive and less specific than the other tests. It is found in about 60% of people with coeliac disease and 25% of those  with dermatitis herpetiformis.

4- Positive blood tests are not regarded as definitive proof of coeliac disease, and generally require biopsy confirmation. Many doctors consider coeliac disease to be diagnosed where the patient has positive blood tests and shows improved symptoms  after the adoption of a gluten-free diet, while others require at least one upper endoscopy with biopsy. The problem with not doing a biopsy at all is that patients later commonly want to know if they really have coeliac disease and need to remain gluten restricted. A diagnosis with biopsy confirmation at the time of initial diagnosis eliminates this common clinical problem. A small minority of doctors advocate gluten-free diets even for symptom-free patients who have not had an endoscopy but have had a positive blood test, because some confirmed coeliacs are completely symptom-free throughout their lives; in symptom-free patients, the purpose of the diet is to avoid nutritional deficiencies, osteoporosis, and intestinal lymphoma.

Other tests that may assist in the diagnosis are a full blood count, electrolytes, renal function and liver enzymes. Coagulation testing may be useful to identify deficiency of vitamin K, which predisposes patients to hemorrhage.

Pathology

The classic pathology changes of coeliac disease in the small bowel are the following:
   -villous atrophy 
   -mucosal inflammation, often with plasma cells and lymphocytes seen in the lamina propria. 
   -crypt hyperplasia

The changes classically improve or reverse after gluten is removed from the diet.

Causes 

The causes are presently presumed to be:
   -Genetic susceptibility to the illness. 
   -A trigger, which could be one of: 
   -An environmental agent, probably a virus or other infection 
   -Stress 
   -Pregnancy 
   -Possible exposure to gluten as a young baby before the gut barrier has developed fully. This 
 association is currently under investigation. 
   -Coeliac disease is associated with other autoimmune diseases; these diseases are also probably a 
 combination of susceptibility and infection.

Autoantigens are probably of major importance in the pathogenesis of coeliac disease (transglutaminase), a trait it shares with many other autoimmune diseases; thyroiditis: thyroglobulin, thyroid peroxidase; multiple sclerosis: myelic basic protein, etc. To some extent infectious agents may increase the risk of certain autoimmune diseases (e.g. Coxsackie B in type 1 diabetes). There are few proofs of infections triggering coeliac disease, however. Some researchers have suggested that smoking is protective against coeliac disease. Results on this topic are however inconsistent, and smoking cannot be recommended as a means to avoid developing coeliac disease.

The timing of the first exposure to gluten is also thought to be important. Babies who were introduced to wheat, barley, or rye at any time in the first three months had five times the risk of developing coeliac over those exposed at 4 to 6 months. Those exposed later had a slightly increased risk relative to those exposed at 4-6 months.

Pathophysiology

Antibodies to the enzyme tissue transglutaminase (tTG) are found in an overwhelming majority of cases, and cross-react to gluten. This has led to the theory that they cause the autoimmune like attack on the bowel lining (which is high in tTG), prompted by the continuous stimulation by the a-1-gliaden fragment of gluten (a 33-mer peptide). This reaction happens almost exclusively in patients with human leukocyte antigen types DQ2 and DQ8, which is inherited in families. Over 95% of coeliac patients carry one or two of the DQ2 or DQ8 genes. Every person carries two HLA-DQ_ genes, one from their mother and one from their father. About 20% of normal people carry HLA-DQ2, which raises the question of what other factors cause a subgroup of  those patients to develop coeliac disease.

The inflammatory process leads to disruption of the structure and function of the small bowel's mucosa, and causes malabsorption (it impairs the body's ability to absorb nutrients and fat-soluble vitamins A, D, E and K from food).

The targets of the immunologic response are gliadin, hordein, and secalin, proteins contained in the gluten component of wheat, barley, and rye respectively. Traditionally, oats have been included in the list as well, but some recent studies have brought into question whether this is necessary. Most probably oats produced symptoms due to cross contamination with other grains in the fields or in the distribution channels. There is at least one oat vendor that claims no cross contamination (McCann's). Maize (corn), sorghum, rice and other carbohydrate rich foods, like potatoes and bananas, are safe for a patient to consume. They do not contain gluten and do not trigger the disease.

  Treatment

The only treatment is a life-long gluten-free diet. At this time no medication will prevent damage, nor prevent the body from attacking the gut when gluten is present. The disease is controlled by strict adherence to a gluten-free diet, which allows the intestines to heal and resolves all symptoms in the vast majority of cases and, depending on how soon the diet is begun, can also eliminate the heightened risk of osteoporosis and intestinal cancer.

In the vast majority of patients, a strict gluten-free diet will relieve the symptoms. A tiny minority of patients suffer from  refractory sprue, which means they do not improve on a gluten-free diet. This may be because the disease has been present for so long that the intestines are no longer able to heal. In other patients, the intestinal damage of coeliac disease may have been aggravated by other problems, such as intolerance to the dietary proteins found in eggs, milk, or soy. Just as a person who is allergic to cats may also happen to be allergic to pollen, a patient with coeliac disease may also happen to have other food intolerances that cause similar symptoms. In rare cases only the complete removal of members of the Gramineae family of plants from the diet will bring about recovery from symptoms.

Clinical trials are underway for a medication that can be taken by coeliacs before eating gluten that will protect against an auto-immune reaction, and hence prevent intestinal damage. Alba Pharmceuticals announced in April, 2006 that Phase I trials   for safety were complete. Phase II trials are expected to begin as early as the summer of 2006. The medication is a zonulin inhibitor peptide; people with several autoimmune disorders including type I diabetes, coeliac disease, multiple sclerosis and rheumatoid arthritis appear to produce high amounts of zonulin. Zonulin is implicated in causing increased permeability of the intestines as related to coeliac disease. 

Epidemiology

Susceptibility to coeliac disease is genetic and many cases are diagnosed in childhood, but the disease can be triggered by environmental factors at any point in life. It is probably most common in the UK, with the average incidence there being 1 in 100 people. With 1 in 250 people diagnosed, Italy also has one of the highest rates of coeliac disease. Those in other countries with British or Italian ancestry are likely to be at risk, owing to the genetic component of the disease and the tendency to feed infants gluten products very early in life in these cultures. People of African, Japanese, and Chinese descent are rarely diagnosed.

It is estimated that 1 in every 133 to 500 persons (up to 3 million) in the United States and Europe are affected by coeliac disease. One study, by the University of Maryland School of Medicine, found an incidence of 1 out of 133 in a study of 13,000 men and women. The disease is not limited to those of European origin; it is found in other races, but the prevalence is not known. Coeliac disease is more common in women than in men. In symptomatic adults, the average delay between onset of symptoms and diagnosis is estimated at 11 years. This lengthy delay appears to be caused by the variety of symptoms  associated with the disease, the fact that some coeliacs have no digestive-tract symptoms at all, and lack of widespread, up-to-date information among doctors.

Epidemiologically, the disease predominates in Northern European populations. Estimates of its frequency among people of European origin range from 1 in 300 to 1 in 500. Some studies indicate that among the Irish, the frequency may be as high as     1 in 133, whilst in the UK the average incidence is 1 in 100. Because it is partly genetic, doctors commonly recommend that the first-degree relatives of diagnosed coeliacs should be tested for the disorder even if they are symptom-free.

In the US, researchers are finding that people with Type I diabetes have a higher risk of coeliac than the other populations. In one study of 125 patients without any specific coeliac symptoms, 12 were confirmed through biopsy as having coeliac.

There is an increased risk of intestinal T-cell lymphoma and osteoporosis in untreated cases. In recent years it has also become more evident that coeliac disease in the pregnant mother could have an adverse effect on the fetus. Offspring to mothers with undiagnosed (and untreated) coeliac disease are more often preterm and low birth weight (weigh less than 2500 grams/5 pounds at birth) than offspring to mothers without coeliac disease. This may be due to the mother's inability to absorb all the nutrients   she eats. In children of women with coeliac disease and a gluten-free treatment there seems to be no such risk increase. Women  with coeliac disease have fertility similar to that of the general female population, but they often have their babies at an older age.
A number of patients with other diseases are often screened for coeliac disease, including patients with type 1 diabetes, iron-deficiency anemia, Down's syndrome, Turner's syndrome, irritable bowel syndrome, lupus, and autoimmune thyroid  disease.

         
Social impact

Lifelong diet
The lifelong diet can be difficult and socially troublesome, especially in young patients, but it is crucial in order to avoid serious health consequences. Teenagers in particular occasionally rebel against the dietary strictures and suffer relapses or complications as a result. The widespread use of wheat byproducts in prepared food, soups and sauces can make dining out problematic. This is especially true in the United States, where coeliac disease is less widely-known among the wider population than it is in Europe. However, certain types of restaurant (for example, Japanese, Thai, Indian, and Latin American) already offer a wide range of gluten-free menu options, and many major restaurant chains have responded to growing awareness of coeliac disease  by posting information about the gluten content of their menu items on their websites.

It is important for coeliacs to understand that one does not "get over" coeliac disease; it is present for life. As coeliac disease   has become better understood, the availability of gluten-free replacements for everyday treats such as muffins, bagels, pasta and the like has continually improved, as has their quality.

It is easy for coeliacs to think they have removed all gluten from their diet, but to continue to consume one or two products that they do not associate with gluten. For example, to eat only gluten-free foods but to continue to drink beer may easily make all that hard work useless. However, even this problem may now be overcome and there are many specialist brews around the world that may be described as gluten free beer.
However, the case of beer raises the main problem of coeliac disease: while the diet is strict and the effects of the disease are serious, the main symptom of the disease can be social isolation with the coeliac afraid to become involved in normal social life. Parties can be difficult, weddings and funerals hard, holidays awkward, meals eaten out a nightmare, travel is made more stressful, and even trips to bars or pubs require the individual to be constantly aware of the disease. It is too easy for the coeliac to withdraw from these normal activities, and coeliacs are often working to create normal activities where they can forget the problem. However, there are widespread alternatives to beer such as cider and wine, which can be used as an alternative. It is important for newly diagnosed coeliacs to ensure that they do get involved in social activities and are not afraid to "make a fuss."


Specialist breads, pastas, and beer

Coeliac disease may isolate individuals due to dietary strictures, but manufacturers are increasingly producing a wide range of very acceptable breads, and some gluten-free pastas are virtually indistinguishable from wheat pasta. Restaurants are beginning  to offer gluten free menus.

Gluten free beer is available and there is now a range of ales and lagers to choose from. While beers made from barley malt are unsafe for coeliacs, a range of gluten free beers have been developed. However, standards of "gluten free" vary around the world. For example, while in the United Kingdom a beer with less than 20 parts per million gluten (20ppm) is "gluten free", in Australia it is not possible to describe any product as such if any gluten can be detected at all. Similarly, some "gluten free" breads can contain low levels of gluten in one country, in another they would contravene labeling or food standards legislation.

It is considered important, therefore, for consumers of all "low gluten" foods and beverages to inform their consultant, and to ensure that even if the obvious symptoms are absent, there are no other negative effects continuing that they are unaware of.  Even the smallest amounts of gluten can worsen osteoporosis risk or predispose for malignancy.

Disclaimer: In no way is this information meant to replace the advice and care from your doctor, or any other medical professional. Patients should inform their doctor/allergist/dermatologist if they are pursuing one of these treatment routes.